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Editorial
. 2008 Sep 2;52(10):851-4.
doi: 10.1016/j.jacc.2008.05.044.

Oxidation, inflammation, and aortic valve calcification peroxide paves an osteogenic path

Dwight A Towler
Editorial

Oxidation, inflammation, and aortic valve calcification peroxide paves an osteogenic path

Dwight A Towler. J Am Coll Cardiol. .
No abstract available

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Figures

Figure 1
Figure 1. Working model of hydrogen peroxide actions during vascular calcification
In response to uncoupled NOS and/or vascular Nox activity, arterial peroxide levels are increased in the setting of impaired peroxidase defenses that dissipate H2O2 signals. In the calcifying aortic valve, uncoupling of NOS activity prominently contributes along with reductions in valve catalase activity(10). H2O2 upregulates Msx2 (21), Runx2/Cbfa1(24), and Wnt/β-catenin cascades (23) necessary for osteogenic differentiation of multipotent vascular osteoprogenitors(3,16). GS-SG, oxidized glutathione.
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