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. 2008 Sep;9(7):509-15.
doi: 10.1016/j.jamda.2008.04.008. Epub 2008 Jul 30.

Neuropsychiatric symptom patterns in hospice-eligible nursing home residents with advanced dementia

Karan S Kverno  1 , Betty S Black, David M Blass, Jeanne Geiger-Brown, Peter V Rabins
Affiliations

Neuropsychiatric symptom patterns in hospice-eligible nursing home residents with advanced dementia

Karan S Kverno et al. J Am Med Dir Assoc. 2008 Sep.

Abstract

Objective: The purpose of this study was to determine whether specific neuropsychiatric symptom patterns could be identified in a cohort of hospice-eligible nursing home residents with advanced dementia.

Methods: Surrogate decision makers gave informed consent to enroll 123 residents from 3 nursing homes. All participating residents met criteria for hospice eligibility and were determined by direct examination at the time of study enrollment to have advanced dementia. Retrospective medical record review was used to collect data on residents' demographics, diagnoses, and the presence of any neuropsychiatric symptoms during the 6 months prior to study enrollment. Latent class analysis (LCA) was used to classify residents based on neuropsychiatric symptom patterns.

Results: Overall, 85% of residents exhibited one or more neuropsychiatric symptoms. LCA revealed that these individuals could be classified into 3 groups: one with low symptom frequencies (36%) considered to be the normative class, one characterized by psychosis and agitation or aggression (23%), and a third characterized by withdrawal or lethargy (41%).

Conclusions: These results add to the growing understanding of neuropsychiatric symptom patterns in advanced dementia and have implications for more dimensional classification and treatment approaches.

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Comment in

  • Behaviors in advanced dementia.
    Volicer L. Volicer L. J Am Med Dir Assoc. 2009 Feb;10(2):146; author reply 146-7. doi: 10.1016/j.jamda.2008.10.017. Epub 2008 Dec 20. J Am Med Dir Assoc. 2009. PMID: 19187886 No abstract available.

References

    1. Blasi Z, Hurley A, Volicer L. End-of-life care in dementia: a review of problems, prospects, and solutions in practice. J Am Med Dir Assoc. 2002;3:57–65. - PubMed
    1. Chan DC, Kasper JD, Black BS, Rabins PV. Presence of behavioral and psychological symptoms predicts nursing home placement in community-dwelling elders with cognitive impairment in univariate but not multivariate analysis. J Gerontol A Biol Sci Med Sci. 2003;58:548–554. - PubMed
    1. Gaugler JE, Duval S, Anderson KA, Kane RL. Predicting nursing home admission in the U.S: A meta-analysis. BMC Geriatr. 2007;19:7–13. - PMC - PubMed
    1. Volicer L, Hurley AC, Blasi ZV. Characteristics of dementia end-of-life care across care settings. Am J Hosp Palliat Care. 2003;20:191–200. - PubMed
    1. Yaffe K, Fox P, Newcomer R, et al. Patient and caregiver characteristics and nursing home placement in patients with dementia. JAMA. 2002;287:2090–2097. - PubMed

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