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Review
. 2008 Aug;23(4):727-30.
doi: 10.3346/jkms.2008.23.4.727.

Benign schwannoma of the liver: a case report

Won Hyun Lee  1 , Tae Hyo Kim, Soong Suk You, Sun Pil Choi, Hyun Ju Min, Hyun Jin Kim, Ok Jae Lee, Gyung Hyuck Ko
Affiliations
Review

Benign schwannoma of the liver: a case report

Won Hyun Lee et al. J Korean Med Sci. 2008 Aug.

Abstract

A primary benign schwannoma of the liver is extremely rare. Only nine cases have been reported in the medical literature worldwide and no case has been reported in Korea previously. A 36-yr-old woman was admitted to our hospital with vague epigastric pain. The ultrasound and computed tomography scan revealed a multi-septated cystic mass in the right lobe of the liver. The mass was resected; it was found to be a 5 x 4 x 2 cm mass filled with reddish yellow fluid. The histological examination confirmed the diagnosis of a benign schwannoma, proven by positive immunoreaction with the neurogenic marker S-100 protein and a negative response to CD34, CD117 and smooth muscle actin. This is the first report of a benign schwannoma of the liver parenchyma in a Korean patient.

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Figures

Fig. 1
Fig. 1
Ultrasound findings of the mass. A 4.5-cm sized round hypoechoic mass with multiple central echogenic bands in the right lobe of the liver (segment V).
Fig. 2
Fig. 2
Abdominal computed tomography shows a 5 cm smooth margined low-attenuating mass in the right lobe of liver (segment V), containing multiple central septations.
Fig. 3
Fig. 3
A photograph showing the cut section of the tumor: The specimen was 5 × 4 × 2 cm. A multi-septated cyst that was previously opened, measuring 4 × 4 cm. The cyst was 1 cm from the resection margin. The cyst contained 10 soft tissues. The wall thickness measured 0.4 cm.
Fig. 4
Fig. 4
(A) Spindle cell tumor with a mixture of two growth patterns, Antoni A and Antoni B, is seen. In the Antoni A pattern of growth, elongated cells were arranged in areas of moderate to high cellularity (black arrow). In the Antoni B pattern of growth, the tumor was less densely cellular, had a loose meshwork of cells, as well as microcysts and myxoids changes (red arrow) (H&E, ×100). (B) Spindle cell tumor with cells arranged in whorls in a storiform pattern is seen (H&E, ×200).
Fig. 5
Fig. 5
A photograph of immunochemical staining with S-100 protein: The tumor is composed of bundles of compact spindle cells that are immunoreactive to the S-100 protein (×200).
See this image and copyright information in PMC

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