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Case Reports
. 2009 Feb;11(1):92-5.
doi: 10.1215/15228517-2008-071. Epub 2008 Aug 29.

Colon perforation during antiangiogenic therapy for malignant glioma

Andrew D Norden  1 , Jan Drappatz, Abigail Slate Ciampa, Lisa Doherty, Debra Conrad LaFrankie, Santosh Kesari, Patrick Y Wen
Affiliations
Case Reports

Colon perforation during antiangiogenic therapy for malignant glioma

Andrew D Norden et al. Neuro Oncol. 2009 Feb.

Abstract

Antiangiogenic drugs have emerged as effective treatment options for patients with recurrent malignant gliomas (MGs). Though this class of drugs is generally well tolerated, rare life-threatening complications, including thromboembolism, hemorrhage, and gastrointestinal (GI) perforation, are reported. We describe six cases of GI perforation among 244 glioma patients (2.5%) during treatment with antiangiogenic agents in combination with chemotherapy and corticosteroids. Two patients succumbed to this complication, and the others recovered. Because GI perforation is a life-threatening yet treatable complication, neurooncologists must have a low threshold to consider it in patients on antiangiogenic drug therapy who present with abdominal pain and other GI complaints.

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