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Review
. 2008 Sep;7(5):579-85.
doi: 10.1517/14740338.7.5.579.

The safety of rosiglitazone in the treatment of type 2 diabetes

Sonal Singh  1 , Yoon K Loke
Affiliations
Review

The safety of rosiglitazone in the treatment of type 2 diabetes

Sonal Singh et al. Expert Opin Drug Saf. 2008 Sep.

Abstract

Background: Cardiovascular disease is the leading cause of mortality among adults with Type 2 diabetes. The thiazolidinediones including rosiglitazone are approved for the treatment of Type 2 diabetes on the basis of their ability to lower blood sugar and surrogate markers of cardiovascular disease.

Objectives: To ascertain the cardiovascular, skeletal and hematologic safety profile of rosiglitazone.

Methods: Synthesis of evidence from recent trials, systematic reviews, meta-analysis, regulatory documents and clinical trials registries of manufacturers.

Conclusion: Rosiglitazone increases the risk of heart failure, myocardial infarction and fractures (in women) with Type 2 diabetes.

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