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. 2008 Sep 15;18(18):4956-8.
doi: 10.1016/j.bmcl.2008.08.024. Epub 2008 Aug 14.

Phenylethyl cinnamides: a new series of alpha-glucosidase inhibitors from the leaves of Aegle marmelos

Preecha Phuwapraisirisan  1 , Thanchanok Puksasook, Jonkolnee Jong-Aramruang, Udom Kokpol
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Phenylethyl cinnamides: a new series of alpha-glucosidase inhibitors from the leaves of Aegle marmelos

Preecha Phuwapraisirisan et al. Bioorg Med Chem Lett. .

Abstract

A series of phenylethyl cinnamides, which included new compounds named anhydromarmeline, aegelinosides A and B, were isolated from Aegle marmelos leaves as alpha-glucosidase inhibitors. The structures of new compounds were characterized by spectroscopic data and chemical degradation. Of compounds isolated, anhydroaegeline revealed the most potent inhibitory effect against alpha-glucosidase with IC(50) value of 35.8 microM. The present result also supports ethnopharmacological use of A. marmelos as a remedy for diabetes mellitus.

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