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Review
. 2009 Apr 8;276(1):1-7.
doi: 10.1016/j.canlet.2008.07.019. Epub 2008 Aug 29.

Regulation of p53R2 and its role as potential target for cancer therapy

Xin Wang  1 , Anna Zhenchuk, Klas G Wiman, Freidoun Albertioni
Affiliations
Review

Regulation of p53R2 and its role as potential target for cancer therapy

Xin Wang et al. Cancer Lett. .

Abstract

p53R2, a recently discovered small subunit of human ribonucleotide reductase, is believed to play essential roles in DNA repair, mtDNA synthesis, and protection against oxidative stress. Because of the positive correlation between the level of this protein and drug sensitivity and tumor invasiveness, it constitutes a potential target for anticancer drugs as well as a diagnostic marker in cancer.

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