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Review
. 2009 Jan;20(3):127-31.
doi: 10.1016/j.trim.2008.08.002. Epub 2008 Aug 30.

Can ischemic preconditioning alone really protect organs from ischemia reperfusion injury in transplantation

Yuchuan Huang  1 , Juan Shan, Chuan'en Wang, Jie Ma, Dan Li, Li Li, Shengfu Li, Youping Li
Affiliations
Review

Can ischemic preconditioning alone really protect organs from ischemia reperfusion injury in transplantation

Yuchuan Huang et al. Transpl Immunol. 2009 Jan.

Abstract

Organ transplantation is the only choice for treatment of end-stage disease. The ischemia reperfusion injury (I/RI) occurring after cold ischemia is an unavoidable injury during transplantation, which is also one of the main causes of graft failure. Multiple mechanisms have been postulated to explain tissue injury that occurs after I/RI. It is well-known that ischemic preconditioning (IPC), a short period of ischemia followed by reperfusion, arouses the endogenous mechanism of protection against a sustained ischemic insult. Can ischemic preconditioning alone really protect organs from ischemia reperfusion injury in transplantation?

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