Review
doi: 10.1016/j.biocel.2008.07.018.
Epub 2008 Aug 8.
Monocyte chemoattractant protein-1: a key mediator in inflammatory processes
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- PMID: 18761421
- DOI: 10.1016/j.biocel.2008.07.018
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Review
Monocyte chemoattractant protein-1: a key mediator in inflammatory processes
Int J Biochem Cell Biol.
2009 May.
Abstract
Monocyte chemoattractant protein-1 (MCP-1) is a potent chemoattractant for monocytes and macrophages to areas of inflammation. MCP-1 is a prototypical chemokine subject to coordinated regulation by immunomodulatory agents. Since MCP-1 is implicated in multiple inflammatory diseases, it is a potential target for the treatment of these disorders. In this review, we will provide background information and summarize the MCP-1 structure and signaling pathways. Its involvement in multiple diseases, such as tumour development, atherogenesis and rare autoimmune diseases is also revised.
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