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. 2008 Nov;6(11):1993-5.
doi: 10.1111/j.1538-7836.2008.03142.x.

A complete factor XII deficiency does not affect coagulopathy, inflammatory responses, and lethality, but attenuates early hypotension in endotoxemic mice

T Iwaki, D Cruz-Topete, F J Castellino

A complete factor XII deficiency does not affect coagulopathy, inflammatory responses, and lethality, but attenuates early hypotension in endotoxemic mice

T Iwaki et al. J Thromb Haemost. 2008 Nov.
No abstract available

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Figures

Figure 1
Figure 1
responses of WT and F12−/− mice to LPS challenge. (A) Survival rates of WT and F12−/− mice after implantation of LPS containing osmotic pumps. The solid line depicts the survival curve of WT mice (N=19). The survival at 96 hr was 52.6% of the mice administered LPS. The broken line indicates the survival curve of F12−/− mice (N=30), where 53.3% of the mice survived at 96 hr. The difference of the survival rates between the genotypes was compared using the log-rank and Wilcoxon tests, and no statistical differences were detected. (B) Plasma BK levels after LPS challenge. Plasma levels of BK in WT (black bars, N = 6 mice at each timepoint) and F12−/− mouse plasmas (grey bars, N = 6 mice at each timepoint) at various times after initiation of LPS challenge. * p < 0.05. The minimum detectable concentration was 10 pg/ml, which is the level indicated by the gray bars. (C) Heart rates after LPS challenge. (D) Mean arterial blood pressures after LPS challenge. The black bars indicate WT mice (N=9) and the gray bars depict F12−/− mice (N=9). Pairwise comparisons with statistical significance are indicated as * (p<0.05).
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References

    1. Iwaki T, Castellino FJ. Plasma levels of bradykinin are suppressed in factor XII-deficient mice. Thromb Haemost. 2006;95:1003–10. - PubMed
    1. Iwaki T, Cruz DT, Martin JA, Castellino FJ. A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse. Blood. 2005;105:2364–71. - PubMed
    1. Lay AJ, Donahue D, Tsai MJ, Castellino FJ. Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency. Blood. 2007;109:1884–91. - PMC - PubMed
    1. Pawlinski R, Pedersen B, Schabbauer G, Tencati M, Holscher T, Boisvert W, Andrade-Gordon P, Frank RD, Mackman N. Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia. Blood. 2004;103:1342–7. - PMC - PubMed
    1. Xu H, Ploplis VA, Castellino FJ. A coagulation factor VII deficiency protects against acute inflammatory responses in mice. J Pathol. 2006;210:448–96. - PubMed

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