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Review
. 2008 Sep;8(3):182-3.
doi: 10.1016/j.cmet.2008.08.004.

Membrane redox state and apoptosis: death by peroxide

Joseph Loscalzo  1
Affiliations
Free article
Review

Membrane redox state and apoptosis: death by peroxide

Joseph Loscalzo. Cell Metab. 2008 Sep.
Free article

Abstract

Membrane redox state is governed by the complex interplay between oxidation of unsaturated fatty acids and lipophilic antioxidants. In this issue of Cell Metabolism, Seiler et al. (2008) show that a lipid oxidase, 12/15-lipoxygenase, and a membrane antioxidant enzyme, glutathione peroxidase-4, interact to regulate a novel redox-dependent cell death pathway.

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