Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Oct 30;120(1):108-11.
doi: 10.1016/j.jep.2008.07.048. Epub 2008 Aug 9.

Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication

Chung-Jen Chen  1 , Martin Michaelis, Hseng-Kuang Hsu, Chin-Chuan Tsai, Kunder D Yang, Yang-Chang Wu, Jindrich Cinatl Jr, Hans Wilhelm Doerr
Affiliations

Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication

Chung-Jen Chen et al. J Ethnopharmacol. .

Abstract

Aim of the study: Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by the SARS coronavirus (SARS-CoV). The development of new antiviral agents for SARS-CoV is an important issue. We tried to find potential resource from Traditional Chinese medicine (TCM) for development of new drugs against SARS-CoV.

Materials and methods: Our team recruited the potential TCM formulae (also known as Kampo) from two TCM books, Shang-Han Lun (Discussion of Cold-Induced Disorders) and Wen-Bing Tiau-Bein (Differential Management of Febrile Diseases). Several herbs, which were believed to be beneficial for SARS by experienced TCM doctors were also recruited. In addition, a vegetable polular in Taiwan, China and Malaysia, the tender leaf of Toona sinensis Roem (also known as Cedrela sinensis, belongs to the family Meliacceae) was also recruited under the suggestion of botanic experts. These TCM products and plant extrats were then tested for the effectiveness against SARS-CoV in vitro.

Results: Only TSL-1, the extract from tender leaf of Toona sinensis Roem was found to have an evident effect against SARS-CoV with selectivity index 12 approximately 17.

Conclusion: This paper reports for the first time that extract from a vegetable, the tender leaf of Toona sinensis Roem, can inhibit SARS-CoV in vitro. Thererfore, the tender leaf of Toona sinensis Roem may be an important resource agninst SARS-CoV.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Tender leaves of Toona sinensis Roem were shown as brown-red. Old leaves were shown as green.
Fig. 2
Fig. 2
Toona sinensis Roem was grown in a farm at Tuku, Yunlin County, Taiwan.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Chang H.C., Huang W.C., Hung M.S., Hsu H.K. Extract from the leaves of Toona Sinensis Roemor exerts potent antiproliferative effect on human lung cancer cells. The American Journal of Chinese Medicine. 2002;30:307–314. - PubMed
    1. Chia Y.H. Components of Toona Sinensis: review. In: Hsu H.K., Wong C.F., editors. Taiwan Toona. The R&D Country Club of Toona Sinensis; Kaohsiung, Taiwan: 2007. pp. 130–138. (in Chinese)
    1. Cinatl J., Morgenstern B., Bauer G., Chandra P., Rabenau H., Doerr H.W. Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet. 2003;361:2045–2046. - PMC - PubMed
    1. Cinatl J., Morgenstern B., Bauer G., Chandra P., Rabenau H., Doerr H.W. Treatment of SARS with human interferons. Lancet. 2003;26,362:293–294. - PMC - PubMed
    1. Cinatl J., Michaelis M., Hoever G., Preiser W., Doerr H.W. Development of antiviral therapy for severe acute respiratory syndrome. Antiviral Research. 2005;66:81–97. - PMC - PubMed

Publication types

MeSH terms