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Review
. 2008 Jul;10(9):1072-6.
doi: 10.1016/j.micinf.2008.07.036. Epub 2008 Aug 13.

Do you have a probiotic in your future?

Maria G Dominguez-Bello  1 , Martin J Blaser
Affiliations
Review

Do you have a probiotic in your future?

Maria G Dominguez-Bello et al. Microbes Infect. 2008 Jul.

Abstract

The possibility of using microbes to maintain health, and to prevent or treat disease is a topic as old as microbiology. However, one factor impeding the introduction of effective probiotics has been our very limited understanding of the composition of the human microbiome, as well as the biological requirements for these organisms. With advances in understanding the microbiome and its metagenome in humans and other mammals, we now can build a more robust scientific basis to develop probiotic strategies. Increasing knowledge of intramicrobial competition and cooperation, as well as host-microbe cross-signaling, will facilitate design of new probiotics and the modeling of their deployment, leading to eventual clinical trials.

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Figures

Fig 1
Fig 1
Developmental cross-talk between colonizing microbes and the immune response across the human lifespan
See this image and copyright information in PMC

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