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. 1991 May;45(2):141-143.
doi: 10.1016/0304-3959(91)90179-2.

Local toxicity with subcutaneous methadone. Experience of two centers

E Bruera  1 , R Fainsinger, M Moore, R Thibault, E Spoldi, V Ventafridda
Affiliations

Local toxicity with subcutaneous methadone. Experience of two centers

E Bruera et al. Pain. 1991 May.

Abstract

We report on 8 patients treated with subcutaneous methadone for cancer-related pain at 2 institutions. The success of other subcutaneous agents for pain control has been well demonstrated. It was felt that methadone would be useful due to its low cost. Unfortunately, 7 of the 8 patients experienced adverse reactions at the subcutaneous sites requiring cessation of subcutaneous methadone.

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