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. 2008 Sep 2:6:37.
doi: 10.1186/1477-7827-6-37.

The correlation between endometrial thickness and outcome of in vitro fertilization and embryo transfer (IVF-ET) outcome

Ahlam Al-Ghamdi  1 , Serdar Coskun, Saad Al-Hassan, Rafat Al-Rejjal, Khalid Awartani
Affiliations

The correlation between endometrial thickness and outcome of in vitro fertilization and embryo transfer (IVF-ET) outcome

Ahlam Al-Ghamdi et al. Reprod Biol Endocrinol. .

Abstract

Background: To evaluate the relationship between endometrial thickness on day of human chorionic gonadotrophin administration (hCG) and pregnancy outcome in a large number of consecutive in vitro fertilization and embryo transfer (IVF-ET) cycles.

Methods: A retrospective cohort study including all patients who had IVF-ET from January 2003-December 2005 conducted at a tertiary center.

Results: A total of 2464 cycles were analysed. Pregnancy rate (PR) was 35.8%. PR increased linearly (r = 0.864) from 29.4% among patients with a lining of less than or equal to 6 mm, to 44.4% among patients with a lining of greater than or equal to 17 mm. ROC showed that endometrial thickness is not a good predictor of PR, so a definite cut-off value could not be established (AUC = 0.55).

Conclusion: There is a positive linear relationship between the endometrial thickness measured on the day of hCG injection and PR, and is independent of other variables. Hence aiming for a thicker endometrium should be considered.

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Figures

Figure 1
Figure 1
The ROC and linear regression curves.
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