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Case Reports
. 2008 Sep 2;118(10):e147-8.
doi: 10.1161/CIRCULATIONAHA.108.764779.

Images in cardiovascular medicine. Healing of an asymptomatic carotid plaque ulceration

Ye Qiao  1 , Alik Farber, Elie Semaan, James A Hamilton
Affiliations
Case Reports

Images in cardiovascular medicine. Healing of an asymptomatic carotid plaque ulceration

Ye Qiao et al. Circulation. .
No abstract available

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Figures

Figure 1
Figure 1
Plaque ulceration of the left internal carotid artery. A, In vivo T1W MRI at 3T (repetition time, 1 RR of cardiac cycle; echo time, 10 ms; echo train, 9; 1 average and with heart rate of 50 bpm). B, Gross inspection of the CEA specimen. C, Ex vivo T1W MRI at 11.7T of the specimen. D, Trichrome-stained matched histology. Arrows in A through D indicate plaque ulceration and hemorrhage.
Figure 2
Figure 2
Healing of plaque ulceration and rupture: serial MRI of the right carotid artery with histology validation. A, Magnetic resonance angiography showing internal (ICA), common (CCA), and external (ECA) carotid arteries and vertebral artery (VA); B, F, and J, Contiguous T1W MRI slices oriented at the lines in A. Plaque ulcerations are detected in the common carotid (arrows in J). C, G, and K, T1W MRI obtained 2 months later at the same location. Comparing to J, a new bright signal band is observed in K (arrows). D, H, and L, Matched histology with trichrome stain (Scale bar=1 mm). Blue-stained collagen-rich fibrous tissue is seen on top of red-stained hemorrhage of L, and it is thin in D and H. E, Fibrous cap disruption in the ICA (arrow, inset box of D). I, Immunostaining of glycophorin A (brown, inset box of H). M, Sirius red stain viewed under polarized light (inset box of L). Collagen type I is red and collagen type III is green.
See this image and copyright information in PMC

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References

    1. Qiao Y, Ronen I, Viereck J, Ruberg FL, Hamilton JA. Identification of atherosclerotic lipid deposits by diffusion-weighted imaging. Arterioscler Thromb Vasc Biol. 2007;27:1440–1446. - PMC - PubMed
    1. Burke AP, Kolodgie FD, Farb A, Weber DK, Malcom GT, Smialek J, Virmani R. Healed plaque ruptures and sudden coronary death: evidence that subclinical rupture has a role in plaque progression. Circulation. 2001;103:934–940. - PubMed
    1. Holmes JW, Yamashita H, Waldman LK, Covell JW. Scar remodeling and transmural deformation after infarction in the pig. Circulation. 1994;90:411–420. - PubMed
    1. Chu B, Yuan C, Takaya N, Shewchuk JR, Clowes AW, Hatsukami TS. Serial high-spatial-resolution, multisequence magnetic resonance imaging studies identify fibrous cap rupture and penetrating ulcer into carotid atherosclerotic plaque. Circulation. 2006;113:e660–e661. - PubMed

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