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Review
. 2008 Sep;133(36):1785-94; quiz 1795-6.
doi: 10.1055/s-0028-1082813. Epub 2008 Sep 2.

[Treatment of diffuse large B-cell lymphoma]

[Article in German]
B Gleissner  1 , C Zwick, M Pfreundschuh
Affiliations
Review

[Treatment of diffuse large B-cell lymphoma]

[Article in German]
B Gleissner et al. Dtsch Med Wochenschr. 2008 Sep.

Abstract

Diffuse large B-cell lymphoma represent 40% of all lymphoma. The development of dose-dense chemotherapeutic regimens and the application of the monoclonal CD20 antibody rituximab improve the prognosis significantly. Evaluation of clinical risk factors (age, stage, LDH, ECOG performance status, number of extranodal involvement) at initial diagnosis are the most important approaches for risk stratification that allows risk adapted modifications of the standard R-CHOP regimen.

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