Review
doi: 10.4238/vol7-3gmr486.
Leukemia/lymphoma-associated gene fusions in normal individuals
Affiliations
- PMID: 18767247
- DOI: 10.4238/vol7-3gmr486
Item in Clipboard
Review
Leukemia/lymphoma-associated gene fusions in normal individuals
Genet Mol Res.
2008.
Free article
Abstract
Hematopoietic neoplasias are characterized by recurrent chromosomal aberrations that result in the formation of gene fusions and the subsequent expression of chimeric proteins with unique properties. However, in recent years, different lymphoma/leukemia-associated rearrangements, such as BCR/ABL, IGH/BCL2, ETV6/RUNX1 and MLL duplications, have been detected in healthy individuals. The presence of these rearrangements indicates that such translocations can be generated in normal hematopoietic cells without apparent oncogenic consequences. This article reviews and discusses the data available in the literature.
Similar articles
-
"Exposure to the insecticides permethrin and malathion induces leukemia and lymphoma-associated gene aberrations in vitro".Toxicol In Vitro. 2017 Oct;44:17-26. doi: 10.1016/j.tiv.2017.06.013. Epub 2017 Jun 15. Toxicol In Vitro. 2017. PMID: 28624474
-
Leukemia- and lymphoma-associated genetic aberrations in healthy individuals.Ann Hematol. 2002 Feb;81(2):64-75. doi: 10.1007/s00277-002-0427-x. Epub 2002 Jan 30. Ann Hematol. 2002. PMID: 11907785 Review.
-
Common leukemia- and lymphoma-associated genetic aberrations in healthy individuals.J Mol Diagn. 2011 Mar;13(2):213-9. doi: 10.1016/j.jmoldx.2010.10.009. J Mol Diagn. 2011. PMID: 21354057 Free PMC article.
-
Interphase-FISH screening for eight common rearrangements in pediatric B-cell precursor acute lymphoblastic leukemia.Int J Lab Hematol. 2013 Aug;35(4):406-15. doi: 10.1111/ijlh.12031. Epub 2012 Nov 28. Int J Lab Hematol. 2013. PMID: 23190578
-
[Leukemia- and lymphoma-associated flow cytometric, cytogenetic, and molecular genetic aberrations in healthy individuals].Orv Hetil. 2012 Apr 8;153(14):531-40. doi: 10.1556/OH.2012.29334. Orv Hetil. 2012. PMID: 22450142 Review. Hungarian.
Cited by
-
Dissect: detection and characterization of novel structural alterations in transcribed sequences.Bioinformatics. 2012 Jun 15;28(12):i179-87. doi: 10.1093/bioinformatics/bts214. Bioinformatics. 2012. PMID: 22689759 Free PMC article.
-
Enhancing B-Cell Malignancies-On Repurposing Enhancer Activity towards Cancer.Cancers (Basel). 2021 Jun 29;13(13):3270. doi: 10.3390/cancers13133270. Cancers (Basel). 2021. PMID: 34210001 Free PMC article. Review.
-
Hypothesis: Artifacts, Including Spurious Chimeric RNAs with a Short Homologous Sequence, Caused by Consecutive Reverse Transcriptions and Endogenous Random Primers.J Cancer. 2015 May 1;6(6):555-67. doi: 10.7150/jca.11997. eCollection 2015. J Cancer. 2015. PMID: 26000048 Free PMC article. Review.
-
Methylation of the nonhomologous end joining repair pathway genes does not explain the increase of translocations with aging.Age (Dordr). 2014;36(6):9730. doi: 10.1007/s11357-014-9730-4. Epub 2014 Nov 16. Age (Dordr). 2014. PMID: 25399073 Free PMC article.
-
How animal models of leukaemias have already benefited patients.Mol Oncol. 2013 Apr;7(2):224-31. doi: 10.1016/j.molonc.2013.01.006. Epub 2013 Feb 11. Mol Oncol. 2013. PMID: 23453906 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous
