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Comment
. 2008 Sep 9;105(36):13193-4.
doi: 10.1073/pnas.0807440105. Epub 2008 Sep 3.

The origin of adaptive phenotypes

Austin L Hughes  1
Affiliations
Comment

The origin of adaptive phenotypes

Austin L Hughes. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Structure of bovine rhodopsin, showing (space-filled, red) the 12 amino acid sites at which changes affecting λmax have occurred in the evolution of vertebrates (3).
See this image and copyright information in PMC

Comment on

References

    1. Hughes AL. Looking for Darwin in all the wrong places: The misguided quest for positive selection at the nucleotide sequence level. Heredity. 2007;99:364–373. - PubMed
    1. Hughes AL, Friedman R. Codon-based tests of positive selection, branch lengths, and the evolution of mammalian immune system genes. Immunogenetics. 2008;60:495–506. - PMC - PubMed
    1. Yokoyama S, Tada T, Zhang H, Britt L. Elucidation of phenotypic adaptations: Molecular analyses of dim-light vision proteins in vertebrates. Proc Natl Acad Sci USA. 2008;105:13480–13485. - PMC - PubMed
    1. Hughes AL. Adaptive Evolution of Genes and Genomes. New York: Oxford Univ Press; 1999.
    1. Hughes AL, Nei M. Pattern of nucleotide substitution at MHC class I loci reveals overdominant selection. Nature. 1988;335:167–170. - PubMed

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