Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2008 Nov;38(11):1201-9.
doi: 10.1007/s00247-008-0984-9. Epub 2008 Sep 4.

Correlation of lung abnormalities on high-resolution CT with clinical graft-versus-host disease after allogeneic versus autologous bone marrow transplantation in children

Laura Merlini  1 , Irene Maria Olivia Borzani, Mehrak Anooshiravani, Isabelle Rochat, Ayse Hulya Ozsahin, Sylviane Hanquinet
Affiliations
Comparative Study

Correlation of lung abnormalities on high-resolution CT with clinical graft-versus-host disease after allogeneic versus autologous bone marrow transplantation in children

Laura Merlini et al. Pediatr Radiol. 2008 Nov.

Abstract

Background: Late-onset noninfectious pulmonary complications (LONIPCs) are life-threatening complications of bone marrow transplantation (BMT). Several pathological patterns are described in the literature with different prognoses, and with different relationships to graft-versus-host disease (GVHD). The role of high-resolution CT (HRCT) is not yet well established.

Objective: To illustrate different patterns of LONIPCs on HRCT in allogeneic versus autologous BMT in order to investigate the correlation with chronic GVHD (cGVHD).

Materials and methods: A total of 67 HRCT scans were performed in 24 patients with noninfectious pulmonary disease at least 3 months after BMT (16 allogeneic, 8 autologous). Abnormality patterns and extension on HRCT images were correlated with the clinical outcome and with the severity of cGVHD.

Results: Of 24 patients, 9 showed LONIPCs (1 autologous, 8 allogeneic). There was a significant association between abnormalities on HRCT and severe cGVHD (P = 0.038), with no specific pattern. Prognosis seemed to be related to the severity of cGVHD and not to the extent of abnormalities on HRCT.

Conclusion: The significant association between abnormalities on HRCT and severe GVHD suggests that LONIPCs can be a pulmonary manifestation of the disease. HRCT is a useful tool when combined with clinical data.

PubMed Disclaimer

References

    1. Clin Radiol. 1992 Jun;45(6):371-7 - PubMed
    1. Am Rev Respir Dis. 1993 Jun;147(6 Pt 1):1601-6 - PubMed
    1. Bone Marrow Transplant. 1995 Jun;15(6):825-8 - PubMed
    1. Am J Respir Crit Care Med. 2004 Jul 1;170(1):22-48 - PubMed
    1. Semin Hematol. 2006 Jan;43(1):42-52 - PubMed

Publication types