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Comment
. 2008 Sep 9;14(3):193-4.
doi: 10.1016/j.ccr.2008.08.005.

Bony endothelium: tumor-mediated transdifferentiation?

Catherine M Verfaillie  1
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Bony endothelium: tumor-mediated transdifferentiation?

Catherine M Verfaillie. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Dudley et al. (2008) report that endothelial cells (ECs) from murine prostate tumors unexpectedly differentiate into cells with characteristics of bone and cartilage and that human and murine prostate tumors contain "calcified" ECs. These observations open the possibility for targeted antiangiogenic therapy.

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