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Comment
. 2008 Sep 5;321(5894):1304-5.
doi: 10.1126/science.1163785.

An enzyme assembly line

Janet L Smith  1 , David H Sherman
Affiliations
Comment

An enzyme assembly line

Janet L Smith et al. Science. .
No abstract available

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Figures

Figure
Figure. Assembly-line proliferation
The dissociated FAS-II (A) evolved into the homodimeric FAS-I (B) [dotted lines outline disordered parts of the FAS-I structure (2); lighter shades indicate inactivated DH, KR, and MT domains]. Duplication of an ancestral FAS-I gene, followed by selective deletion, yielded the canonical extension modules of modern PKS pathways (C). An even richer diversity of polyketides arose by domain recruitment. For example, the CurF protein of the hybrid PKS/NRPS for curacin A (10) includes decarboxylase (ECH), cyclopropanase (Cpn), and NRPS domains (D).
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References

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