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Case Reports
. 2008 Sep-Oct;30(5):482-4.
doi: 10.1016/j.genhosppsych.2008.03.007. Epub 2008 Jul 23.

Neuroleptic malignant syndrome without fever after addition of oxcarbazepine to long-term treatment with amisulpride

Petros Angelopoulos  1 , Maria Markopoulou, Kyriakos Kyamidis, Konstantinos Bobotas
Affiliations
Case Reports

Neuroleptic malignant syndrome without fever after addition of oxcarbazepine to long-term treatment with amisulpride

Petros Angelopoulos et al. Gen Hosp Psychiatry. 2008 Sep-Oct.

Abstract

Objective: Our goal was to report a case of malignant neuroleptic syndrome in a patient administered with both oxcarbazepine (OXCBZ) and amisulpride (AM).

Method: We present a case of a young man who presented with symptoms of malignant neuroleptic syndrome after progressive titration of OXCBZ (1,200 mg) added to the long-term treatment with AM (800 mg).

Results: After discontinuation of AM and administration of dopaminergic drugs, his clinical symptoms improved gradually.

Conclusion: This case suggests that clinicians should consider the risk of neuroleptic malignant syndrome when OXCBZ is coadministered to patients undergoing long-term treatment with neuroleptics.

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