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. 2008 Sep;71(9):1657-9.
doi: 10.1021/np8004024. Epub 2008 Sep 6.

11-Hydroxymonocerin from the plant endophytic fungus Exserohilum rostratum

Ruengrit Sappapan  1 , Damrong Sommit, Nattaya Ngamrojanavanich, Somchai Pengpreecha, Suthep Wiyakrutta, Nongluksna Sriubolmas, Khanitha Pudhom
Affiliations

11-Hydroxymonocerin from the plant endophytic fungus Exserohilum rostratum

Ruengrit Sappapan et al. J Nat Prod. 2008 Sep.

Erratum in

  • J Nat Prod. 2008 Dec;71(12):2080

Abstract

A new analogue of monocerin, 11-hydroxymonocerin (2), along with monocerin (1) and 12-hydroxymonocerin (3) were isolated from cultures of Exserohilum rostratum, a fungal strain endophytic in Stemona sp. The structure of 2 was determined by analysis of NMR and MS data and by comparison of spectroscopic data to those of 1. Monocerin (1) and 11-hydroxymonocerin (2) displayed activity against Plasmodium falciparum (K1, multidrug-resistant strain) with IC50 values of 0.68 and 7.70 microM, respectively. None of the compounds were cytotoxic against any of the tumor cell lines tested.

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