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Review
. 2008 Oct;10(5):410-4.
doi: 10.1007/s11906-008-0076-0.

Pharmacologic modulation of ACE2 expression

María José Soler  1 , Clara Barrios, Raymond Oliva, Daniel Batlle
Affiliations
Review

Pharmacologic modulation of ACE2 expression

María José Soler et al. Curr Hypertens Rep. 2008 Oct.

Abstract

Angiotensin-converting enzyme 2 (ACE2) is an enzymatically active homologue of angiotensin-converting enzyme that degrades angiotensin I, angiotensin II, and other peptides. Recent studies have shown that under pathologic conditions, ACE2 expression in the kidney is altered. In this review, we briefly summarize recent studies dealing with pharmacologic interventions that modulate ACE2 expression. ACE2 amplification may have a potential therapeutic role for kidney disease and hypertension.

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References

    1. Danilczyk U., Penninger J.M. Angiotensin-converting enzyme II in the heart and the kidney. Circ Res. 2006;98:463–471. doi: 10.1161/01.RES.0000205761.22353.5f. - DOI - PubMed
    1. Tipnis S.R., Hooper N.M., Hyde R., et al. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem. 2000;275:332 38–332 43. doi: 10.1074/jbc.M002615200. - DOI - PubMed
    1. Donoghue M., Hsieh F., Baronas E., et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1–9. Circ Res. 2000;87:E1–E9. - PubMed
    1. Crackower M.A., Sarao R., Oudit G.Y., et al. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 2002;417:822–828. doi: 10.1038/nature00786. - DOI - PubMed
    1. Xie X., Chen J., Wang X., et al. Age-and gender-related difference of ACE2 expression in rat lung. Life Sci. 2006;78:2166–2171. doi: 10.1016/j.lfs.2005.09.038. - DOI - PMC - PubMed

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