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. 2008 Sep 5;134(5):888-888.e1.
doi: 10.1016/j.cell.2008.08.027.

SnapShot: nucleic acid helicases and translocases

James M Berger

SnapShot: nucleic acid helicases and translocases

James M Berger. Cell. .
No abstract available

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Figures

Figure
Figure
Topology diagrams of helicase and translocase superfamily members. The central RecA and AAA+ folds are built from an ancestral αβα ASCE domain (turquoise). The relative position of bound nucleotide is shown, and certain nucleoside-triphosphate binding motifs are highlighted (sensor I; sensor II; arginine-finger; Walker-A and Walker B motifs). The catalytic glutamic acid of the Walker-B motif can occupy alternative positions in some subfamilies (pale red spheres). The AAA+ sensor-I amino acid is generally a polar residue that is also found in other ASCE proteins. Triangles represent common insertion points for domains or secondary structural elements that are specific to select helicase and translocase groups (e.g. domains IB and IIB of SF-I helicases, or the pre-Sensor I β-hairpin of AAA+ proteins). The diverse placement of arginine finger elements arises from distinct tertiary and quaternary arrangements of domains or subunits in different subfamilies.
See this image and copyright information in PMC

References

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