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. 2008 Jul;61(7):464-73.
doi: 10.1038/ja.2008.63.

Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671

Hans-Peter Fiedler  1 , Anke Dieter, Tobias A M Gulder, Inga Kajahn, Andreas Hamm, Ros Brown, Amanda L Jones, Michael Goodfellow, Werner E G Müller, Gerhard Bringmann
Affiliations

Genoketides A1 and A2, new octaketides and biosynthetic intermediates of chrysophanol produced by Streptomyces sp. AK 671

Hans-Peter Fiedler et al. J Antibiot (Tokyo). 2008 Jul.

Abstract

The new aromatic polyketides genoketide A1, genoketide A2 and prechrysophanol glucuronide are biosynthetic intermediates of the octaketide chrysophanol. They were isolated from the alkaliphilic strain Streptomyces sp. AK 671 together with the new metabolite chrysophanol glucuronide. The structures of the compounds were elucidated by mass spectrometry and NMR methods. Genoketide A2 exhibited a slight and prechrysophanol glucuronide a more pronounced inhibition of the proliferation of L5178y lymphoma cells.

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