Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Oct 1;130(39):12874-5.
doi: 10.1021/ja805088r. Epub 2008 Sep 6.

Intramolecular arylcyanation of alkenes catalyzed by nickel/AlMe2Cl

Yoshiaki Nakao  1 , Shiro Ebata, Akira Yada, Tamejiro Hiyama, Masashi Ikawa, Sensuke Ogoshi
Affiliations

Intramolecular arylcyanation of alkenes catalyzed by nickel/AlMe2Cl

Yoshiaki Nakao et al. J Am Chem Soc. .

Abstract

A catalyst system derived from nickel and cocatalytic AlMe2Cl effects the intramolecular arylcyanation of alkenes. The reaction takes place in an exclusive exo-dig manner to give a wide range of nitriles having a benzylic quaternary carbon in good yields. Detailed investigations are described on the scope and mechanism as well as preliminary results on the asymmetric version of the reaction to provide novel access to chiral quaternary stereocenters.

PubMed Disclaimer

LinkOut - more resources