doi: 10.1021/np800435c.
Epub 2008 Sep 9.
Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa
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- PMID: 18778099
- DOI: 10.1021/np800435c
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Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa
J Nat Prod.
2008 Sep.
Abstract
Seven new indole alkaloids of the Aspidosperma type, jerantinines A-G (1-7), were isolated from a leaf extract of the Malayan Tabernaemontana corymbosa. The structures were established using NMR and MS analysis. Five of the alkaloids isolated and two derivatives (1-5, 8, 9) displayed pronounced in vitro cytotoxicity against human KB cells (IC50 < 1 microg/mL).
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