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. 2008 Sep;71(9):1591-4.
doi: 10.1021/np800435c. Epub 2008 Sep 9.

Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa

Kuan-Hon Lim  1 , Osamu Hiraku, Kanki Komiyama, Toh-Seok Kam
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Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa

Kuan-Hon Lim et al. J Nat Prod. 2008 Sep.

Abstract

Seven new indole alkaloids of the Aspidosperma type, jerantinines A-G (1-7), were isolated from a leaf extract of the Malayan Tabernaemontana corymbosa. The structures were established using NMR and MS analysis. Five of the alkaloids isolated and two derivatives (1-5, 8, 9) displayed pronounced in vitro cytotoxicity against human KB cells (IC50 < 1 microg/mL).

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