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. 2008 Oct 1;18(19):5242-4.
doi: 10.1016/j.bmcl.2008.08.066. Epub 2008 Aug 22.

Triazole oxytocin antagonists: identification of aryl ether replacements for a biaryl substituent

Alan Brown  1 , Lindsay Brown, T Bruce Brown, Andrew Calabrese, Dave Ellis, Nicholas Puhalo, Chris R Smith, Olga Wallace, Lesa Watson
Affiliations

Triazole oxytocin antagonists: identification of aryl ether replacements for a biaryl substituent

Alan Brown et al. Bioorg Med Chem Lett. .

Abstract

Several potent aryl ether/triazole oxytocin antagonists are described. The lead compound in this series had significantly improved aqueous solubility over related systems containing a biaryl substituent.

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