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Comment
. 2008 Sep 11;4(3):194-5.
doi: 10.1016/j.chom.2008.08.006.

Coinfection alters the playing field: herpesviruses induce acyclovir to inhibit HIV

Jack T Stapleton  1 , Henry H Balfour Jr
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Free article
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Coinfection alters the playing field: herpesviruses induce acyclovir to inhibit HIV

Jack T Stapleton et al. Cell Host Microbe. .
Free article

Abstract

The antiherpes drug acyclovir was found to inhibit HIV following its phosphorylation by human herpesviruses, providing a hypothesis to explain the observed beneficial effects of acyclovir therapy on HIV viral load and HIV disease progression. This report underscores the importance of studying HIV in the context of microbial copathogens.

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