Extinction retention predicts improvement in social anxiety symptoms following exposure therapy
- PMID: 18781661
- DOI: 10.1002/da.20511
Extinction retention predicts improvement in social anxiety symptoms following exposure therapy
Abstract
Background: Several researchers have argued that basic research on extinction learning can guide efforts to enhance the efficacy of exposure-based therapy. At the basis of this translational research paradigm is the assumption that extinction retention is important to the outcome of exposure-based therapy. This study is the first to examine the relationship between extinction retention, which comprises the amount of fear reduction that is retained between two exposure sessions and improvement in anxiety symptoms following exposure treatment.
Methods: Adults (N=90), participating in two separate studies, who received three sessions of repeated exposure to public speaking provided ratings of peak fear during exposure treatment and completed the Liebowitz Social Anxiety Scale Self-Report version, LSAS-SR, Baker et al. [2002: Behav Res Ther 40:701-715] at baseline, posttreatment, and follow-up.
Results: After controlling for within-session extinction, extinction retention accounted for significant variance in the improvement of LSAS-SR scores over time.
Conclusions: Our findings suggest that the consolidation of extinction learning into long-term memory is associated with improvements in fear and avoidance related to social situations following exposure therapy. Implications for exposure therapy augmentation studies are discussed.
Similar articles
-
Augmentation of exposure therapy with D-cycloserine for social anxiety disorder.Arch Gen Psychiatry. 2006 Mar;63(3):298-304. doi: 10.1001/archpsyc.63.3.298. Arch Gen Psychiatry. 2006. PMID: 16520435 Clinical Trial.
-
Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear.Arch Gen Psychiatry. 2004 Nov;61(11):1136-44. doi: 10.1001/archpsyc.61.11.1136. Arch Gen Psychiatry. 2004. PMID: 15520361 Clinical Trial.
-
A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy.Biol Psychiatry. 2008 Jun 15;63(12):1118-26. doi: 10.1016/j.biopsych.2008.01.012. Epub 2008 Mar 7. Biol Psychiatry. 2008. PMID: 18313643
-
Enhancing exposure therapy for anxiety disorders with glucocorticoids: from basic mechanisms of emotional learning to clinical applications.J Anxiety Disord. 2010 Mar;24(2):223-30. doi: 10.1016/j.janxdis.2009.10.011. Epub 2009 Nov 6. J Anxiety Disord. 2010. PMID: 19962269 Review.
-
Optimizing inhibitory learning during exposure therapy.Behav Res Ther. 2008 Jan;46(1):5-27. doi: 10.1016/j.brat.2007.10.003. Epub 2007 Oct 7. Behav Res Ther. 2008. PMID: 18005936 Review.
Cited by
-
Brain structure correlates of individual differences in the acquisition and inhibition of conditioned fear.Cereb Cortex. 2011 Sep;21(9):1954-62. doi: 10.1093/cercor/bhq253. Epub 2011 Jan 24. Cereb Cortex. 2011. PMID: 21263037 Free PMC article.
-
Exercise Augmentation of Exposure Therapy for PTSD: Rationale and Pilot Efficacy Data.Cogn Behav Ther. 2015;44(4):314-27. doi: 10.1080/16506073.2015.1012740. Epub 2015 Feb 23. Cogn Behav Ther. 2015. PMID: 25706090 Free PMC article. Clinical Trial.
-
Serotonin transporter polyadenylation polymorphism modulates the retention of fear extinction memory.Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5493-8. doi: 10.1073/pnas.1202044109. Epub 2012 Mar 19. Proc Natl Acad Sci U S A. 2012. PMID: 22431634 Free PMC article.
-
Enhancing panic and smoking reduction treatment with D-Cycloserine: A pilot randomized clinical trial.Drug Alcohol Depend. 2020 Mar 1;208:107877. doi: 10.1016/j.drugalcdep.2020.107877. Epub 2020 Jan 22. Drug Alcohol Depend. 2020. PMID: 32004998 Free PMC article. Clinical Trial.
-
The role of stress and fear in the development of mental disorders.Psychiatr Clin North Am. 2014 Dec;37(4):535-46. doi: 10.1016/j.psc.2014.08.010. Epub 2014 Oct 11. Psychiatr Clin North Am. 2014. PMID: 25455064 Free PMC article. Review.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Research Materials