doi: 10.1021/ja804489m.
Epub 2008 Sep 10.
Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases
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- PMID: 18781746
- DOI: 10.1021/ja804489m
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Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases
J Am Chem Soc.
.
Abstract
A homotyrosine based seleninic acid irreversibly inhibits protein tyrosine phosphatases by forming a covalent selenosulfide linkage with the active site cysteine sulfhydryl specifically. The details of the event are revealed by model synthetic studies and by kinetic, mass spectrometric, and crystallographic characterization.
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