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Review
. 2008 Oct;13 Suppl 1(Suppl 1):28-34.
doi: 10.1111/j.1523-5378.2008.00633.x.

Helicobacter and gastric malignancies

António Carlos Ferreira  1 , Hajime Isomoto, Masatsugu Moriyama, Toshio Fujioka, José Carlos Machado, Yoshio Yamaoka
Affiliations
Review

Helicobacter and gastric malignancies

António Carlos Ferreira et al. Helicobacter. 2008 Oct.

Abstract

Individuals infected with Helicobacter pylori, a stomach colonizing bacteria, have an increased risk of developing gastric malignancies. The risk for developing cancer relates to the physiologic and histologic changes that H. pylori infection induces in the stomach. In the last year numerous studies have been conducted in order to characterize the association between H. pylori infection and gastric cancer. These studies range from epidemiologic approaches aiming at the identification of environmental, host genetic, and bacterial factors associated with risk of gastric cancer, to molecular and cell biology approaches aiming at understanding the interaction between H. pylori and the transforming epithelial cell. In this review an account of the last year's research activity on the relationship between H. pylori and gastric cancer will be given.

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Conflict of interest statement

Conflicts of interest

Y. Yamaoka has received a research funding grant from NIH ROI (DK 62813). The remaining authors have declared no conflicts.

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