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Editorial
. 2008 Sep 11;359(11):1171-3.
doi: 10.1056/NEJMe0805943.

Renal phosphate-transporter regulatory proteins and nephrolithiasis

Moshe Levi, Sophia Breusegem
Editorial

Renal phosphate-transporter regulatory proteins and nephrolithiasis

Moshe Levi et al. N Engl J Med. .

Erratum in

  • N Engl J Med. 2009 Sep 17;361(12):1220. Bruesegem, Sophia [corrected to Breusegem, Sophia]
No abstract available

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Conflict of interest statement

No other potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1. Postulated Mechanisms of Nephrolithiasis and Phosphate-Transport Inhibition
Panel A shows postulated mechanisms by which a primary renal phosphate leak could result in hypercalciuria and formation of renal stones. Panel B shows postulated mechanisms of how parathyroid hormone (PTH) signaling through the PTH type 1 receptor (PTH1R) in the apical brush-border membrane and basolateral membrane results in the phosphorylation of NHERF1, which leads to disassociation of NHERF1–NPT2a complexes and endocytosis (internalization) of apical NPT2a protein and inhibition of phosphate transport. The mechanisms of interactions between PTH and PDZ domain containing 1 protein (PDZK1) and of PTH-induced NPT2c endocytosis remain unknown. PKA denotes protein kinase A, and PKC protein kinase C.
See this image and copyright information in PMC

Comment on

References

    1. Tessier J, Petrucci M, Trouvé ML, et al. A family-based study of metabolic phenotypes in calcium urolithiasis. Kidney Int. 2001;60:1141–7. - PubMed
    1. Prié D, Ravery V, Boccon-Gibod L, Friedlander G. Frequency of renal phosphate leak among patients with calcium nephrolithiasis. Kidney Int. 2001;60:272–6. - PubMed
    1. Iwaki T, Sandoval-Cooper MJ, Tenehouse HS, Castellino FJ. A missense mutation in the sodium phosphate co-transporter Slc34a1 impairs phosphate homeostasis. J Am Soc Nephrol. 2008 June 11; (Epub ahead of print) - PMC - PubMed
    1. Prié D, Huart V, Bakouh N, et al. Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2 sodium–phosphate cotransporter. N Engl J Med. 2002;347:983–91. - PubMed
    1. Lapointe JY, Tessier J, Paquette Y, et al. NPT2a gene variation in calcium nephrolithiasis with renal phosphate leak. Kidney Int. 2006;69:2261–7. - PubMed