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. 2008 Oct 1;22(15):2035-8.
doi: 10.1097/QAD.0b013e3283112d29.

Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy

Giulia Marchetti  1 , Giusi M Bellistrì, Elisa Borghi, Camilla Tincati, Stefania Ferramosca, Maria La Francesca, Giulia Morace, Andrea Gori, Antonella D'Arminio Monforte
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Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy

Giulia Marchetti et al. AIDS. .

Abstract

Patients with inefficient CD4+ T-cell recovery on virogically suppressive highly active antiretroviral therapy constitute a major clinical hurdle given the threat of HIV/AIDS disease progression. We show heightened circulating lipopolysaccharide associated with plasma enterobacterial DNA and highly activated Ki67+CD4+CD8+ in 24 immunologic-nonresponders (CD4+ T-cell < or = 200; HIV-RNA < or = 50) compared with 11 full responders (CD4+ T-cell > or= 400; HIV-RNA < or = 50). These data provide novel insight into INRs pathogenesis, since they correlate augmented systemic translocation of microbial bioproducts with T-cell hyperactivation.

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