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Review
. 2008 Sep;8(5):617-33.
doi: 10.1586/14737159.8.5.617.

Metabolomics-based methods for early disease diagnostics

G A Nagana Gowda  1 , Shucha Zhang, Haiwei Gu, Vincent Asiago, Narasimhamurthy Shanaiah, Daniel Raftery
Affiliations
Review

Metabolomics-based methods for early disease diagnostics

G A Nagana Gowda et al. Expert Rev Mol Diagn. 2008 Sep.

Abstract

The emerging field of metabolomics, in which a large number of small-molecule metabolites from body fluids or tissues are detected quantitatively in a single step, promises immense potential for early diagnosis, therapy monitoring and for understanding the pathogenesis of many diseases. Metabolomics methods are mostly focused on the information-rich analytical techniques of NMR spectroscopy and mass spectrometry (MS). Analysis of the data from these high-resolution methods using advanced chemometric approaches provides a powerful platform for translational and clinical research and diagnostic applications. In this review, the current trends and recent advances in NMR- and MS-based metabolomics are described with a focus on the development of advanced NMR and MS methods, improved multivariate statistical data analysis and recent applications in the area of cancer, diabetes, inborn errors of metabolism and cardiovascular diseases.

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Figures

Figure 1
Figure 1
Schematic representation illustrating the NMR/MS based metabolomics workflow.
See this image and copyright information in PMC

References

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