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. 2008 Sep 12;321(5895):1462.
doi: 10.1126/science.1162525.

A mutation in hairless dogs implicates FOXI3 in ectodermal development

Cord Drögemüller  1 , Elinor K Karlsson, Marjo K Hytönen, Michele Perloski, Gaudenz Dolf, Kirsi Sainio, Hannes Lohi, Kerstin Lindblad-Toh, Tosso Leeb
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A mutation in hairless dogs implicates FOXI3 in ectodermal development

Cord Drögemüller et al. Science. .

Abstract

Mexican and Peruvian hairless dogs and Chinese crested dogs are characterized by missing hair and teeth, a phenotype termed canine ectodermal dysplasia (CED). CED is inherited as a monogenic autosomal semidominant trait. With genomewide association analysis we mapped the CED mutation to a 102-kilo-base pair interval on chromosome 17. The associated interval contains a previously uncharacterized member of the forkhead box transcription factor family (FOXI3), which is specifically expressed in developing hair and teeth. Mutation analysis revealed a frameshift mutation within the FOXI3 coding sequence in hairless dogs. Thus, we have identified FOXI3 as a regulator of ectodermal development.

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