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Editorial
. 2008 Oct;128(10):2354-6.
doi: 10.1038/jid.2008.236.

Germline MC1R variants and BRAF mutant melanoma

Elke Hacker  1 , Nicholas K Hayward
Affiliations
Free article
Editorial

Germline MC1R variants and BRAF mutant melanoma

Elke Hacker et al. J Invest Dermatol. 2008 Oct.
Free article

Abstract

Recent studies have demonstrated that melanocortin-1 receptor (MC1R) variants increase the risk of melanomas harboring BRAF mutations. This finding provides insight into the relationship between host genotype and selection for somatic mutation type. Additional larger studies are required in diverse populations to further examine the interaction between MC1R and BRAF in different melanoma subtypes.

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  • MC1R variants increase risk of melanomas harboring BRAF mutations.
    Fargnoli MC, Pike K, Pfeiffer RM, Tsang S, Rozenblum E, Munroe DJ, Golubeva Y, Calista D, Seidenari S, Massi D, Carli P, Bauer J, Elder DE, Bastian BC, Peris K, Landi MT. Fargnoli MC, et al. J Invest Dermatol. 2008 Oct;128(10):2485-90. doi: 10.1038/jid.2008.67. Epub 2008 Mar 27. J Invest Dermatol. 2008. PMID: 18368129 Free PMC article.

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