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Editorial
. 2008 Oct;128(10):2357-61.
doi: 10.1038/jid.2008.249.

Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism

Daniel D Bikle  1
Affiliations
Editorial

Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism

Daniel D Bikle. J Invest Dermatol. 2008 Oct.

Abstract

More than 1 million skin cancers occur annually in the United States--of which 80% are basal-cell carcinoma (BCC), 16% are squamous-cell carcinoma (SCC), and 4% are melanomas--making skin cancer by far the most common cancer (Greenlee et al., 2001). UVR is the major etiologic agent. UV wavelengths shorter than 280 nm (UVC) are absorbed by the ozone layer and do not reach the earth. UV wavelengths longer than 320 nm (UVA) have limited ability to induce the characteristic mutations in DNA seen in epidermal cancers. Thus, UVB, with a spectrum between 280 and 320 nm, is the major cause of these cancers (Freeman et al., 1989), but this is the same spectrum required for vitamin D production in the skin. Is there a link?

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Conflict of interest statement

CONFLICT OF INTEREST

The author states no conflict of interest.

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References

    1. Aszterbaum M, Rothman A, Johnson RL, Fisher M, Xie J, Bonifas JM et al. (1998) Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome. J Invest Dermatol 110:885–8 - PubMed
    1. Aszterbaum M, Epstein J, Oro A, Douglas V, LeBoit PE, Scott MP et al. (1999) Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Nat Med 5:1285–91 - PubMed
    1. Bartkova J, Horejsi Z, Koed K, Kramer A, Tort F, Zieger K et al. (2005) DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434:864–70 - PubMed
    1. Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N et al. (2006) Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444:633–7 - PubMed
    1. Berg RJ, Rebel H, van der Horst GT, van Kranen HJ, Mullenders LH, van Vloten WA et al. (2000) Impact of global genome repair versus transcription-coupled repair on ultraviolet carcinogenesis in hairless mice. Cancer Res 60:2858–63 - PubMed

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