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. 2008 Oct;27(10):1107-12.
doi: 10.1080/15257770802341285.

One-pot synthesis of antiviral acyclovir and other nucleosides derivatives using doped natural phosphate as lewis acid catalyst

Hassan B Lazrek  1 , Laila Baddi, Michael Smietana, Jean-Jacques Vasseur, Said Sebti, Mohamed Zahouily
Affiliations

One-pot synthesis of antiviral acyclovir and other nucleosides derivatives using doped natural phosphate as lewis acid catalyst

Hassan B Lazrek et al. Nucleosides Nucleotides Nucleic Acids. 2008 Oct.

Abstract

Natural phosphate doped with iodine or potassium iodide is an active catalyst for the one-pot synthesis of acyclonucleosides. To demonstrate the utility of the new catalyst system, the highly important antiviral drug acyclovir was directly and regioselectively obtained from NAcG with no byproducts.

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