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. 2008 Oct;44(1):168-71.
doi: 10.1016/j.cyto.2008.07.471. Epub 2008 Sep 11.

Relationship of elevated osteoprotegerin with insulin resistance, CRP, and TNF-alpha levels in men with type 2 diabetes

Subhashini Yaturu  1 , Justin Rains, Sushil K Jain
Affiliations

Relationship of elevated osteoprotegerin with insulin resistance, CRP, and TNF-alpha levels in men with type 2 diabetes

Subhashini Yaturu et al. Cytokine. 2008 Oct.

Abstract

Aim: Our objective of this study is to investigate the relationship between plasma osteoprotegerin (OPG) levels in type 2 diabetes and its relationship with the insulin resistance, HbA(1c), CRP, and TNF-alpha levels.

Methods: In a cross-sectional study, levels of OPG were determined in 50 subjects with type 2 diabetes and 59 control subjects without diabetes. The OPG levels between the groups were compared and their correlation with insulin resistance, glycemia and inflammatory markers CRP and TNF-alpha was determined.

Results: OPG levels were elevated in subjects with diabetes (6.8+/-0.27 pmol/l), compared to control subjects (5.7+/-0.26 pmol/l). OPG levels significantly correlate with insulin, insulin resistance, CRP, and TNF-alpha.

Conclusion: OPG levels are significantly correlated with insulin resistance and may reflect the proinflammatory state in type 2 diabetes.

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