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. 2009 May;115(1-2):177-82.
doi: 10.1016/j.jad.2008.07.022. Epub 2008 Sep 13.

Immune system dysregulation in adolescent major depressive disorder

Vilma Gabbay  1 , Rachel G Klein, Carmen M Alonso, James S Babb, Melissa Nishawala, Georgette De Jesus, Glenn S Hirsch, Pauline M Z Hottinger-Blanc, Charles J Gonzalez
Affiliations

Immune system dysregulation in adolescent major depressive disorder

Vilma Gabbay et al. J Affect Disord. 2009 May.

Abstract

Background: A large body of evidence suggests that immune system dysregulation is associated with Major Depressive Disorder (MDD) in adults. This study extends this work to adolescent MDD to examine the hypotheses of immune system dysregulation in adolescents with MDD, as manifested by significantly: (i) elevated plasma levels of cytokines (interferon [IFN]-gamma, tumor necrosis factor-alpha, interleukin [IL]-6, IL-1beta, and IL-4); and (ii) Th1/Th2 cytokine imbalance shifted toward Th1 as indexed by increased IFN-gamma/IL-4.

Method: Thirty adolescents with MDD (19 females; 13 medication-free/naïve; ages 12-19) of at least 6 weeks duration and a minimum severity score of 40 on the Children's Depression Rating Scale-Revised, and 15 healthy comparisons (8 females), group-matched for age, were enrolled. Plasma cytokines were examined using enzyme-linked immunosorbent assay. Mann-Whitney test was used to compare subjects with MDD and controls.

Results: Adolescents with MDD had significantly elevated plasma IFN-gamma levels (3.38+/-11.8 pg/ml versus 0.37+/-0.64 pg/ml; p<0.003), and IFN-gamma/IL-4 ratio (16.6+/-56.5 versus 1.76+/-2.28; p=0.007). A trend for IL-6 to be elevated in the MDD group was also observed (1.52+/-2.88 pg/ml versus 0.49+/-0.90 pg/ml; p=0.09). Importantly, findings remained evident when medicated subjects were excluded.

Conclusions: Findings suggest that immune system dysregulation may be associated with adolescent MDD, with an imbalance of Th1/Th2 shifted toward Th1, as documented in adult MDD. Larger studies with medication-free adolescents should follow.

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Conflict of interest statement

Conflict of interest

Drs. Vilma Gabbay, Rachel G. Klein, Carmen M. Alonso, James S. Babb, Melissa Nishawala, Georgette De Jesus, Glenn S. Hirsch, Pauline M.Z. Hottinger-Blanc, and Charles J. Gonzalez report no conflicts of interest.

References

    1. Bartlett JA, Schleifer SJ, Demetrikopoulos MK, Keller SE. Immune differences in children with and without depression. Biol. Psychiatry. 1995;38:771–774. - PubMed
    1. Birmaher B, Rabin BS, Garcia MR, Jain U, Whiteside TL, Williamson DE, al Shabbout M, Nelson BC, Dahl RE, Ryan ND. Cellular immunity in depressed, conduct disorder, and normal adolescents: role of adverse life events. J. Am. Acad. Child Adolesc. Psych. 1994;33:671–678. - PubMed
    1. Birmaher B, Ryan ND, Williamson DE, Brent DA, Kaufman J. Childhood and adolescent depression: a review of the past 10 years. Part II. J. Am. Acad. Child Adolesc. Psych. 1996;35:1575–1583. - PubMed
    1. Bonaccorso S, Marino V, Biondi M, Grimaldi F, Ippoliti F, Maes M. Depression induced by treatment with interferon-alpha in patients affected by hepatitis C virus. J. Affect. Disord. 2002;72:237–241. - PubMed
    1. Brambilla F, Monteleone P, Maj M. Interleukin-1beta and tumor necrosis factor-alpha in children with major depressive disorder or dysthymia. J. Affect. Disord. 2004;78:273–277. - PubMed

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