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Review
. 2008:631:229-36.
doi: 10.1007/978-0-387-78885-2_16.

Inhibitors targeting two-component signal transduction

Takafumi Watanabe  1 , Ario Okada, Yasuhiro Gotoh, Ryutaro Utsumi
Affiliations
Review

Inhibitors targeting two-component signal transduction

Takafumi Watanabe et al. Adv Exp Med Biol. 2008.

Abstract

A two-component signal transduction system (TCS) is an attractive target for antibacterial agents. In this chapter, we review the TCS inhibitors developed during the past decade and introduce novel drug discovery systems to isolate the inhibitors of the YycG/YycF system, an essential TCS for bacterial growth, in an effort to develop a new class of antibacterial agents.

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