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Comment
. 2008 Sep 15;14(18):5643-5.
doi: 10.1158/1078-0432.CCR-08-1557.

Urokinase-type plasminogen activator receptor: a beacon of malignancy?

Ronny Drapkin  1 , Adam Clauss, Steven Skates
Affiliations
Comment

Urokinase-type plasminogen activator receptor: a beacon of malignancy?

Ronny Drapkin et al. Clin Cancer Res. .

Abstract

Discriminating between benign and malignant disease is a pivotal diagnostic issue in the care of women with pelvic masses. Identification of serum biomakers that can rellably make the distinction would aid in the proper referral for patient care and may provide leads in the development of early detection strategies.

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The uPAR is a glycosylated extracellular receptor that is covalently linked to the outer layer of the cell membrane via a glycosyl phosphotidylinositol (GPI) anchor. uPAR consists of three cysteine-rich domains (DI, DII, and DIII) connected by two short linker regions. The N-terminus of the uPAR domain I is the primary site for the binding of uPA.
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