Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Aug 5;13(8):1551-69.
doi: 10.3390/molecules13081551.

5-Fluorouracil: mechanisms of resistance and reversal strategies

Ning Zhang  1 , Ying Yin, Sheng-Jie Xu, Wei-Shan Chen
Affiliations
Review

5-Fluorouracil: mechanisms of resistance and reversal strategies

Ning Zhang et al. Molecules. .

Abstract

The purpose of this work is to review the published studies on the mechanisms of action and resistance of 5-fluorouracil. The review is divided into three main sections: mechanisms of anti-tumor action, studies of the resistance to the drug, and procedures for the identification of new genes involved in resistance with microarray techniques. The details of the induction and reversal of the drug resistance are also described.

PubMed Disclaimer

Figures

Figure 1
Figure 1
a) 5-FU, b) uracil.
See this image and copyright information in PMC

References

    1. Grem J.L. 5-Fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development. Invest New Drugs. 2000;18:299–313. doi: 10.1023/A:1006416410198. - DOI - PubMed
    1. Rutman R.J., Cantarow A., Paschkis K.E. Studies on 2-acetylaminofluorene carcinogenesis: III. The utilization of uracil-2-C14 by pre–neoplastic rat liver. Cancer Res. 1954;14:119–123. - PubMed
    1. Hulme A.T., Price S.L., Tocher D.A. A New Polymorph of 5-Fluorouracil Found Following Computational Crystal Structure Predictions. J. Am. Chem. Soc. 2005;127:1116–1117. doi: 10.1021/ja044336a. - DOI - PubMed
    1. Singh U.P., Ghose R., Ghose A.K., Sodhi A., Singh S.M., Singh R.K. The effect of histidine on the structure and antitumor activity of metal-5-halouracil complexes. J. Inorg. Biochem. 1989;37:25–39. - PubMed
    1. Thomas D.M., Zalcberg J.R. 5-fluorouracil: a pharmacological paradigm in the use of cytotoxics. Clin. Exp. Pharmacol. Physiol. 1998;25:887–895. - PubMed

MeSH terms

LinkOut - more resources