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Review
. 2008 Oct;74(7):849-51.
doi: 10.1038/ki.2008.390.

Uremic lung: new insights into a forgotten condition

Paul J Scheel  1 , Manchang Liu, Hamid Rabb
Affiliations
Free article
Review

Uremic lung: new insights into a forgotten condition

Paul J Scheel et al. Kidney Int. 2008 Oct.
Free article

Abstract

The high mortality rate of acute kidney injury (AKI) despite advances in dialysis led to a renewed appreciation of the impact of AKI on distant organ dysfunction. Mechanistic studies demonstrated that AKI induces increased lung vascular permeability, soluble and cellular inflammation, and dysregulated salt and water channels. AKI also affects the brain, heart, liver, bone marrow, and gastrointestinal tract. Klein et al. now demonstrate that interleukin-6 is a direct mediator of AKI-induced lung changes.

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