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. 2008 Sep 16:8:118.
doi: 10.1186/1471-2334-8-118.

Outcome of HIV-associated Pneumocystis pneumonia in hospitalized patients from 2000 through 2003

Saba Radhi  1 , Travis Alexander, Michelle Ukwu, Samer Saleh, Alison Morris
Affiliations

Outcome of HIV-associated Pneumocystis pneumonia in hospitalized patients from 2000 through 2003

Saba Radhi et al. BMC Infect Dis. .

Abstract

Background: Pneumocystis pneumonia (PCP) remains a leading cause of morbidity and mortality in HIV-infected persons. Epidemiology of PCP in the recent era of highly active antiretroviral therapy (HAART) is not well known and the impact of HAART on outcome of PCP has been debated.

Aim: To determine the epidemiology of PCP in HIV-infected patients and examine the impact of HAART on PCP outcome.

Methods: We performed a retrospective cohort study of 262 patients diagnosed with PCP between January 2000 and December 2003 at a county hospital at an academic medical center. Death while in the hospital was the main outcome measure. Multivariate modeling was performed to determine predictors of mortality.

Results: Overall hospital mortality was 11.6%. Mortality in patients requiring intensive care was 29.0%. The need for mechanical ventilation, development of a pneumothorax, and low serum albumin were independent predictors of increased mortality. One hundred and seven patients received HAART before hospitalization and 16 patients were started on HAART while in the hospital. HAART use either before or during hospitalization was not associated with mortality.

Conclusion: Overall hospital mortality and mortality predictors are similar to those reported earlier in the HAART era. PCP diagnoses in HAART users likely represented failing HAART regimens or non-compliance with HAART.

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Figures

Figure 1
Figure 1
Number of cases of Pneumocystis pneumonia admitted to Los Angeles County-University of Southern California hospital and number of cases requiring intensive care unit (ICU) admission by year.
See this image and copyright information in PMC

References

    1. Dore GJ, Li Y, McDonald A, Ree H, Kaldo JM. Impact of highly active antiretroviral therapy on individual AIDS-defining illness incidence and survival in Australia. J Acquir Immune Defic Syndr. 2002;29:388–395. - PubMed
    1. Palella FJ, Jr, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA, Aschman DJ, Holmberg SD. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med. 1998;338:853–860. doi: 10.1056/NEJM199803263381301. - DOI - PubMed
    1. Kaplan JE, Hanson D, Dworkin MS, Frederick T, Bertolli J, Lindegren ML, Holmberg S, Jones JL. Epidemiology of human immunodeficiency virus-associated opportunistic infections in the United States in the era of highly active antiretroviral therapy. Clin Infect Dis. 2000;30:S5–14. doi: 10.1086/313843. - DOI - PubMed
    1. Mocroft A, Katlama C, Johnson AM, Pradier C, Antunes F, Mulcahy F, Chiesi A, Phillips AN, Kirk O, Lundgren JD. AIDS across Europe, 1994–98: the EuroSIDA study. Lancet. 2000;356:291–296. doi: 10.1016/S0140-6736(00)02504-6. - DOI - PubMed
    1. Detels R, Tarwater P, Phair JP, Margolick J, Riddler SA, Munoz A. Effectiveness of potent antiretroviral therapies on the incidence of opportunistic infections before and after AIDS diagnosis. AIDS. 2001;15:347–355. doi: 10.1097/00002030-200102160-00008. - DOI - PubMed

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