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Review
. 2008 Sep 17:6:52.
doi: 10.1186/1479-5876-6-52.

The cancer secretome: a reservoir of biomarkers

Hua Xue  1 , Bingjian Lu, Maode Lai
Affiliations
Review

The cancer secretome: a reservoir of biomarkers

Hua Xue et al. J Transl Med. .

Abstract

Biomarkers are pivotal for cancer detection, diagnosis, prognosis and therapeutic monitoring. However, currently available cancer biomarkers have the disadvantage of lacking specificity and/or sensitivity. Developing effective cancer biomarkers becomes a pressing and permanent need. The cancer secretome, the totality of proteins released by cancer cells or tissues, provides useful tools for the discovery of novel biomarkers. The focus of this article is to review the recent advances in cancer secretome analysis. We aim to elaborate the approaches currently employed for cancer secretome studies, as well as its applications in the identification of biomarkers and the clarification of carcinogenesis mechanisms. Challenges encountered in this newly emerging field, including sample preparation, in vivo secretome analysis and biomarker validation, are also discussed. Further improvements on strategies and technologies will continue to drive forward cancer secretome research and enable development of a wealth of clinically valuable cancer biomarkers.

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Figures

Figure 1
Figure 1
Secretome preparation from the conditioned media of in vitro cells culture.
See this image and copyright information in PMC

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